TY - JOUR
T1 - Hormonal treatment in pregnancy
T2 - A possible risk factor for neuroblastoma
AU - Mandel, M.
AU - Toren, A.
AU - Rechavi, G.
AU - Dor, J.
AU - Ben‐Bassat, I.
AU - Neumann, Y.
PY - 1994
Y1 - 1994
N2 - In the last 4 years, 24 cases of neuroblastoma were treated in the Pediatric Hematology‐Oncology Unit at the Chaim Sheba Medical Center, 8 of whom were under 1 year of age. Four of them were the product of a pregnancy‐induced or preserved by gonadotropins, clomiphene citrate, or progestational hormones. These drugs are known to produce a higher than normal level of estradiol or progestrone in the early stages of pregnancy. Our observation led to the hypothesis that high levels of progestational hormones given during pregnancy are a risk factor for neuroblastoma in infancy. © 1994 Wiley‐Liss, Inc.
AB - In the last 4 years, 24 cases of neuroblastoma were treated in the Pediatric Hematology‐Oncology Unit at the Chaim Sheba Medical Center, 8 of whom were under 1 year of age. Four of them were the product of a pregnancy‐induced or preserved by gonadotropins, clomiphene citrate, or progestational hormones. These drugs are known to produce a higher than normal level of estradiol or progestrone in the early stages of pregnancy. Our observation led to the hypothesis that high levels of progestational hormones given during pregnancy are a risk factor for neuroblastoma in infancy. © 1994 Wiley‐Liss, Inc.
KW - gonadotropins
KW - neuroblastoma in infancy
KW - neuroblastoma in situ
KW - progestational hormones
UR - http://www.scopus.com/inward/record.url?scp=0028356288&partnerID=8YFLogxK
U2 - 10.1002/mpo.2950230212
DO - 10.1002/mpo.2950230212
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C2 - 8202036
AN - SCOPUS:0028356288
SN - 0098-1532
VL - 23
SP - 133
EP - 135
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 2
ER -
