Hormonal Changes Related to Impairment of Cervical Mucus in Cycles Stimulated by Clomiphene Citrate

Rami Langer*, Abraham Golan, Raphael Ron‐El, Mordechai Pansky, Menachem Neuman, Eliahu Caspi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: The levels of luteinizing hormone (LH), follicular stimulating hormone (FSH), 17‐oestradiol (E2), progesterone (P), and testosterone (T) were determined for the early, midfollicular and periovulatory phase of spontaneous and clomiphene citrate (CC) induced cycles in 5 patients who responded with appearance of hostile cervical mucus (Group A) and 5 patients whose cervical mucus remained unchanged during the same treatment (Group B). The patients with hostile mucus were further investigated during a third cycle stimulated by CC and ethinyloestradiol (EE). Patients treated with CC for induction of ovulation who developed hostile cervical mucus showed higher levels of LH and T in the midfollicular phase of the menstrual cycle and significantly higher levels of T in the periovulatory period compared to patients with unchanged mucus. EE treatment induced a drop in the elevated LH and T levels and improved the cervical score. No change in E2 levels was noted. A direct effect of EE on the cervical glands together with the centrally mediated lowering of serum T are suggested to be responsible for improving the cervical mucus.

Original languageEnglish
Pages (from-to)254-256
Number of pages3
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Volume30
Issue number3
DOIs
StatePublished - Aug 1990

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