Homomeric and heteromeric complexes among TGF-Β and BMP receptors and their roles in signaling

Marcelo Ehrlich, Daniel Horbelt, Barak Marom, Petra Knaus, Yoav I. Henis

Research output: Contribution to journalReview articlepeer-review

Abstract

Transforming growth factor-β (TGF-β) ligands and bone morphogenetic proteins (BMPs) play myriad roles in many biological processes and diseases. Their pluripotent activities are subject to multiple levels of regulation, including receptor oligomerization, endocytosis, association with co-receptors, cellular scaffolds or membrane domains, as well as transcriptional control. In this review, we focus on TGF-β and BMP receptor homomeric and heteromeric complex formation and their modulation by ligand binding, which regulate signaling on a near-immediate timescale. We discuss the current structural, biochemical and biophysical evidence for the oligomerization of these receptors, and the potential roles of distinct oligomeric interactions in signaling.

Original languageEnglish
Pages (from-to)1424-1432
Number of pages9
JournalCellular Signalling
Volume23
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • BMP
  • Patch-FRAP
  • Protein-protein interactions
  • Receptor oligomerization
  • Signaling
  • TGF-β

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