@article{438f6b5bbceb4cf6bee84d6f11658822,
title = "Homomeric and heteromeric complexes among TGF-Β and BMP receptors and their roles in signaling",
abstract = "Transforming growth factor-β (TGF-β) ligands and bone morphogenetic proteins (BMPs) play myriad roles in many biological processes and diseases. Their pluripotent activities are subject to multiple levels of regulation, including receptor oligomerization, endocytosis, association with co-receptors, cellular scaffolds or membrane domains, as well as transcriptional control. In this review, we focus on TGF-β and BMP receptor homomeric and heteromeric complex formation and their modulation by ligand binding, which regulate signaling on a near-immediate timescale. We discuss the current structural, biochemical and biophysical evidence for the oligomerization of these receptors, and the potential roles of distinct oligomeric interactions in signaling.",
keywords = "BMP, Patch-FRAP, Protein-protein interactions, Receptor oligomerization, Signaling, TGF-β",
author = "Marcelo Ehrlich and Daniel Horbelt and Barak Marom and Petra Knaus and Henis, {Yoav I.}",
note = "Funding Information: The work in the authors' laboratories was supported in part by grants from the Israel Science Foundation (grant 158/09 , to Y.I.H.), the German-Israeli Foundation for Scientific Research and Development (GIF, grant 932–244.13/2006 , to Y.I.H. and P.K.), the Deutsche Forschungsgemeinschaft (grant DFG–SFB 449 , to P.K.) and the Sonnenfeld Stiftung (to D.H.). Y.I.H. is an incumbent of the Zalman Weinberg Chair in Cell Biology.",
year = "2011",
month = sep,
doi = "10.1016/j.cellsig.2011.04.004",
language = "אנגלית",
volume = "23",
pages = "1424--1432",
journal = "Cellular Signalling",
issn = "0898-6568",
publisher = "Elsevier Inc.",
number = "9",
}