Homology between an endogenous viral LTR and sequences inserted in an activated cellular oncogene

Edward L. Kuff, Anita Feenstra, Kira Lueders, Gideon Rechavi, David Givol, Eli Canaani

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, some of us reported1 the detection and molecular cloning of a rearranged cellular oncogene, designated rc-mos, from a non-virally-induced mouse myeloma, XRPC24. Recombinant λ phage DNA containing the rc-mos gene was active in transforming NIH 3T3 cells in a transfection assay, whereas recombinant DNA containing the unrearranged c-mos gene was not. In rc-mos, coding sequences from the 5′ end of c-mos were found to have been displaced by a novel cellular element whose nucleotide sequence was reported. We now document the fact that a 349-base pair (bp) segment of the novel DNA immediately adjacent to the retained c-mos sequences in rc-mos has close homology with the long terminal repeat (LTR) of a known intracisternal A-particle gene. This homology was mentioned in Nature recently2 after it had been brought to the attention of the editors (N. Hozumi and R. Hawley, personal communication).

Original languageEnglish
Pages (from-to)547-548
Number of pages2
JournalNature
Volume302
Issue number5908
DOIs
StatePublished - 1983
Externally publishedYes

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