Homogeneity features of dynamic systems are known to provide for a number of general practically important features. In particular, the finite-time convergence is easily proved, and the asymptotic accuracy is readily calculated in the presence of input noises, delays and discrete sampling. General uncertain single-input-single-output regulation problems are only solvable by means of discontinuous control via the so-called high-order sliding modes (HOSM). The homogeneity approach facilitates the design and investigation of new HOSM controllers, featuring such attractive properties as practical continuity of the control in the presence of noises. Robust output-feedback controllers are produced, using robust exact homogeneous differentiators. The asymptotic accuracy of the obtained controllers is the best possible under given circumstances. The dangerous chattering effect is removed by means of a standard procedure. The resulting systems are robust with respect to the presence of unaccounted-for fast stable dynamics of actuators and sensors. Simulation results and applications are presented in the fields of control, signal and image processing.