Homocysteine levels in newly admitted schizophrenic patients

Julia Applebaum, Hady Shimon, Ben Ami Sela, R. H. Belmaker, Joseph Levine*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We previously found a marked elevation of plasma homocysteine in young male schizophrenic patients in hospital. It seemed important to determine if this finding is already present in newly admitted schizophrenic patients. Serum homocysteine levels were studied in 184 consecutively admitted schizophrenic patients and 305 control subjects from an employee screening program. Homocysteine levels were markedly increased in this population of newly admitted schizophrenic patients, especially in young males. Newly admitted male schizophrenic patients have elevated homocysteine levels that cannot be explained on the basis of poor hospital nutrition. Smoking may raise homocysteine by 1-2 μM/L but this is not a large enough effect to explain our findings.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalJournal of Psychiatric Research
Issue number4
StatePublished - 2004


  • Neurotoxicity
  • Schizophrenia
  • Serum homocysteine


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