Hodgkin's variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL study group

Tamar Tadmor, Lev Shvidel, Neta Goldschmidt, Rosa Ruchlemer, Riva Fineman, Osnat Bairey, Naomi Rahimi-Levene, Yair Herishanu, Mona Yuklea, Ariela Arad, Ariel Aviv, Aaron Polliack

Research output: Contribution to journalArticlepeer-review

Abstract

Backround: Richter syndrome (RS) is the development of an aggressive lymphoid malignancy, in chronic lymphocytic leukemia (CLL). Most are diffuse large B-cell lymphomas (DLBCL), however in 10-15% of RS, there is transformation to Hodgkin lymphoma, termed "Hodgkin variant" (HV). In the present retrospective study we summarize the Israeli experience with HV-RS, and analyze demographic data, relevant laboratory and clinical parameters, and outcome. Patients and Methods: We collected and analyzed data from 119 patients with RS from 12 Centers in Israel during 1996-2010 and identified 16 cases with "Hodgkin's variant". Results: The median age was 58 years, and 67% were males. The median time from CLL diagnosis to development of HV was 5.9 (range=0.8-11.9) years and the median survival was 39.5 months, compared to 9 months for the cases with RS-DLBCL. Conclusion: Hodgkin variant appears to differ from DLBCL-RS and is clinically less aggressive. However, compared to de novo Hodgkin's lymphoma, HV-RS has a worse prognosis.

Original languageEnglish
Pages (from-to)785-790
Number of pages6
JournalAnticancer Research
Volume34
Issue number2
StatePublished - 1 Feb 2014
Externally publishedYes

Keywords

  • CLL.
  • Chronic lymphocytic leukemia
  • Hodgkin's lymphoma
  • Hodgkin's variant
  • Richter syndrome
  • Richter transformation

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