TY - JOUR
T1 - HMG improves IVF outcome in patients with high basal FSH/LH ratio
T2 - A preliminary study
AU - Orvieto, Raoul
AU - Homburg, Roy
AU - Meltcer, Simion
AU - Rabinson, Jacob
AU - Anteby, Eyal Y.
AU - Nahum, Ravit
PY - 2009/2
Y1 - 2009/2
N2 - In an attempt to examine the role of human menopausal gonadotrophin (HMG) administration in patients with high basal FSH/LH ratio, patients undergoing at least two IVF cycles, where one included HMG (HMG group) and the other included recombinant FSH (rFSH) only (FSH group), were studied. The use of HMG, in this specific group of patients, produced significantly higher number of top-quality embryos (3.9 ± 3.1 versus 2.5 ± 1.7, respectively; P < 0.05), higher implantation (27.9% versus 5.3%, respectively; P < 0.003) and clinical pregnancy rates (44.4% versus 11.1%, respectively; P < 0.02), as compared with rFSH. Moreover, while the HMG group achieved a significantly higher peak oestradiol concentration (P = 0.04), no differences were observed between the groups in the other ovarian stimulation variables. In conclusion, the use of HMG in patients with high basal FSH/LH ratio, produced significantly higher number of top-quality embryos, and higher implantation and clinical pregnancy rates, compared with rFSH.
AB - In an attempt to examine the role of human menopausal gonadotrophin (HMG) administration in patients with high basal FSH/LH ratio, patients undergoing at least two IVF cycles, where one included HMG (HMG group) and the other included recombinant FSH (rFSH) only (FSH group), were studied. The use of HMG, in this specific group of patients, produced significantly higher number of top-quality embryos (3.9 ± 3.1 versus 2.5 ± 1.7, respectively; P < 0.05), higher implantation (27.9% versus 5.3%, respectively; P < 0.003) and clinical pregnancy rates (44.4% versus 11.1%, respectively; P < 0.02), as compared with rFSH. Moreover, while the HMG group achieved a significantly higher peak oestradiol concentration (P = 0.04), no differences were observed between the groups in the other ovarian stimulation variables. In conclusion, the use of HMG in patients with high basal FSH/LH ratio, produced significantly higher number of top-quality embryos, and higher implantation and clinical pregnancy rates, compared with rFSH.
KW - HMG
KW - IVF outcome
KW - LH ratio
KW - Ovarian stimulation
KW - Pregnancy
KW - RFSH
UR - http://www.scopus.com/inward/record.url?scp=60549095143&partnerID=8YFLogxK
U2 - 10.1016/S1472-6483(10)60257-X
DO - 10.1016/S1472-6483(10)60257-X
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C2 - 19192340
AN - SCOPUS:60549095143
VL - 18
SP - 205
EP - 208
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
SN - 1472-6483
IS - 2
ER -