HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease

Joseph N. Marcus, Margot S. Kruskall, Chester A. Alper, Zuheir Awdeh, Edmond J. Yunis, Robert Westphal, Philip L. Howard, Michael Thaler, Arie Shamiss, Shlomit Orgad, Monica Huszar, Naomi Nussinovitch, Simcha Meisel, Ephraim Gazit, Jacob Lavee, Aram Smolinsky, Takeo Juji, Koki Takahashi, Yoichi Shibata

Research output: Contribution to journalLetterpeer-review

17 Scopus citations


To the Editor: In the July 6 issue, Thaler et al. present two fascinating cases of catastrophic transfusion-associated graft-versus-host disease occurring after open-heart surgery.1 However, I must disagree with their assertion that “cardiac surgery in itself does not render the patient immunodeficient.” On the contrary, it has been well documented that for about the first week after open-heart surgery, patients have profound lymphopenia2 as well as functional deficits associated with T-cell immunity3 4 5 — more so than patients undergoing other types of surgery.2,5 The phenomenon appears to be associated with the use of the cardiopulmonary-bypass pump, although the mechanism is unclear…

Original languageEnglish
Pages (from-to)1004-1007
Number of pages4
JournalNew England Journal of Medicine
Issue number14
StatePublished - 5 Apr 1990
Externally publishedYes


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