HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease

Joseph N. Marcus; Margot S. Kruskall; Chester A. Alper; Zuheir Awdeh; Edmond J. Yunis; Robert Westphal; Philip L. Howard; Michael Thaler; Arie Shamiss; Shlomit Orgad; Monica Huszar; Naomi Nussinovitch; Simcha Meisel; Ephraim Gazit; Jacob Lavee; Aram Smolinsky; Takeo Juji; Koki Takahashi; Yoichi Shibata

doi:10.1056/NEJM199004053221412

HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease

Joseph N. Marcus, Margot S. Kruskall, Chester A. Alper, Zuheir Awdeh, Edmond J. Yunis, Robert Westphal, Philip L. Howard, Michael Thaler, Arie Shamiss, Shlomit Orgad, Monica Huszar, Naomi Nussinovitch, Simcha Meisel, Ephraim Gazit, Jacob Lavee, Aram Smolinsky, Takeo Juji, Koki Takahashi, Yoichi Shibata

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: In the July 6 issue, Thaler et al. present two fascinating cases of catastrophic transfusion-associated graft-versus-host disease occurring after open-heart surgery.¹ However, I must disagree with their assertion that “cardiac surgery in itself does not render the patient immunodeficient.” On the contrary, it has been well documented that for about the first week after open-heart surgery, patients have profound lymphopenia² as well as functional deficits associated with T-cell immunity³ ⁴ ⁵ — more so than patients undergoing other types of surgery.^2,5 The phenomenon appears to be associated with the use of the cardiopulmonary-bypass pump, although the mechanism is unclear…

Original language	English
Pages (from-to)	1004-1007
Number of pages	4
Journal	New England Journal of Medicine
Volume	322
Issue number	14
DOIs	https://doi.org/10.1056/NEJM199004053221412
State	Published - 5 Apr 1990
Externally published	Yes

Access to Document

10.1056/NEJM199004053221412

Cite this

Marcus, J. N., Kruskall, M. S., Alper, C. A., Awdeh, Z., Yunis, E. J., Westphal, R., Howard, P. L., Thaler, M., Shamiss, A., Orgad, S., Huszar, M., Nussinovitch, N., Meisel, S., Gazit, E., Lavee, J., Smolinsky, A., Juji, T., Takahashi, K., & Shibata, Y. (1990). HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease. New England Journal of Medicine, 322(14), 1004-1007. https://doi.org/10.1056/NEJM199004053221412

@article{9c4c997e977e4cdfae3fff3d2f7eceaf,

title = "HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease",

abstract = "To the Editor: In the July 6 issue, Thaler et al. present two fascinating cases of catastrophic transfusion-associated graft-versus-host disease occurring after open-heart surgery.1 However, I must disagree with their assertion that “cardiac surgery in itself does not render the patient immunodeficient.” On the contrary, it has been well documented that for about the first week after open-heart surgery, patients have profound lymphopenia2 as well as functional deficits associated with T-cell immunity3 4 5 — more so than patients undergoing other types of surgery.2,5 The phenomenon appears to be associated with the use of the cardiopulmonary-bypass pump, although the mechanism is unclear…",

author = "Marcus, {Joseph N.} and Kruskall, {Margot S.} and Alper, {Chester A.} and Zuheir Awdeh and Yunis, {Edmond J.} and Robert Westphal and Howard, {Philip L.} and Michael Thaler and Arie Shamiss and Shlomit Orgad and Monica Huszar and Naomi Nussinovitch and Simcha Meisel and Ephraim Gazit and Jacob Lavee and Aram Smolinsky and Takeo Juji and Koki Takahashi and Yoichi Shibata",

year = "1990",

month = apr,

day = "5",

doi = "10.1056/NEJM199004053221412",

language = "אנגלית",

volume = "322",

pages = "1004--1007",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "14",

}

Marcus, JN, Kruskall, MS, Alper, CA, Awdeh, Z, Yunis, EJ, Westphal, R, Howard, PL, Thaler, M, Shamiss, A, Orgad, S, Huszar, M, Nussinovitch, N, Meisel, S, Gazit, E, Lavee, J, Smolinsky, A, Juji, T, Takahashi, K & Shibata, Y 1990, 'HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease', New England Journal of Medicine, vol. 322, no. 14, pp. 1004-1007. https://doi.org/10.1056/NEJM199004053221412

TY - JOUR

T1 - HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease

AU - Marcus, Joseph N.

AU - Kruskall, Margot S.

AU - Alper, Chester A.

AU - Awdeh, Zuheir

AU - Yunis, Edmond J.

AU - Westphal, Robert

AU - Howard, Philip L.

AU - Thaler, Michael

AU - Shamiss, Arie

AU - Orgad, Shlomit

AU - Huszar, Monica

AU - Nussinovitch, Naomi

AU - Meisel, Simcha

AU - Gazit, Ephraim

AU - Lavee, Jacob

AU - Smolinsky, Aram

AU - Juji, Takeo

AU - Takahashi, Koki

AU - Shibata, Yoichi

PY - 1990/4/5

Y1 - 1990/4/5

N2 - To the Editor: In the July 6 issue, Thaler et al. present two fascinating cases of catastrophic transfusion-associated graft-versus-host disease occurring after open-heart surgery.1 However, I must disagree with their assertion that “cardiac surgery in itself does not render the patient immunodeficient.” On the contrary, it has been well documented that for about the first week after open-heart surgery, patients have profound lymphopenia2 as well as functional deficits associated with T-cell immunity3 4 5 — more so than patients undergoing other types of surgery.2,5 The phenomenon appears to be associated with the use of the cardiopulmonary-bypass pump, although the mechanism is unclear…

AB - To the Editor: In the July 6 issue, Thaler et al. present two fascinating cases of catastrophic transfusion-associated graft-versus-host disease occurring after open-heart surgery.1 However, I must disagree with their assertion that “cardiac surgery in itself does not render the patient immunodeficient.” On the contrary, it has been well documented that for about the first week after open-heart surgery, patients have profound lymphopenia2 as well as functional deficits associated with T-cell immunity3 4 5 — more so than patients undergoing other types of surgery.2,5 The phenomenon appears to be associated with the use of the cardiopulmonary-bypass pump, although the mechanism is unclear…

UR - http://www.scopus.com/inward/record.url?scp=0025262143&partnerID=8YFLogxK

U2 - 10.1056/NEJM199004053221412

DO - 10.1056/NEJM199004053221412

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.letter???

AN - SCOPUS:0025262143

SN - 0028-4793

VL - 322

SP - 1004

EP - 1007

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 14

ER -

HLA-Homozygous Donors and Transfusion-Associated Graft-versus-Host Disease

Abstract

Access to Document

Other files and links

Fingerprint

Cite this