HLA and graft-versus-host disease: A population-based study of HLA phenotypes of Jewish and Arabic bone marrow transplanted patients in Israel

Amial Bishara, Charm Brautbar, Arnon Nagler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The relationship between the incidence of graft-versus-host disease (GVHD) and human leukocyte antigens (HLA) was analyzed in HLA-identical sibling bone marrow transplantation donor/recipient pairs from the two major populations in Israel: Jewish and Arabic. HLA phenotypes were significantly different, in both groups, between patients and healthy controls. Among Jews, a higher incidence of GVHD was found with A28, CW3, CW6 of class I and DR7, DQ2 of class II; a lower incidence was found with A2, A26, B14. Among Arabs, a higher incidence of GVHD was found with B41, CW7 of class I, and DR2, DR13 of class II. The development of GVHD is apparently associated with HLA phenotypes specific to each population.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalLeukemia Research
Volume21
Issue number2
DOIs
StatePublished - Feb 1997
Externally publishedYes

Keywords

  • Arabs
  • Class I
  • Class II
  • GVHD
  • HLA antigens
  • Jews

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