Hla alleles in systemic sclerosis: Association with pulmonary hypertension and outcome

P. Langevitz, D. Buskila, D. D. Gladman*, G. A. Darlington, V. T. Farewell, P. Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

HLA antigen distribution was studied in 126 patients with systemic sclerosis (SSc) followed prospectively and compared to that of 325 healthy controls. The frequencies of HLA antigens DR3, DR5 and DRw52 were increased in patients with diffuse skin involvement (P = 0.02, 0.05, 0.03). The presence of DRw52 (relative risk [RR]≫≫≫1) and DRw6 (RR = 54.5) was associated with significantly increased risks of a fatal disease outcome with pulmonary hypertension (PHT). In the absence of PHT, DRw252 was inversely associated with the risk of death. These findings indicate an adverse prognosis in SSc when PHT is present in association with DRw52.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalRheumatology
Volume31
Issue number9
DOIs
StatePublished - Sep 1992
Externally publishedYes

Funding

FundersFunder number
Physicians' Services Incorporated Foundation

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