HIV infection: How effective is drug combination treatment?

Zvi Grossman*, Mark Feinberg, Vladimir Kuznetsov, Dimiter Dimitrov, William Paul

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The rate of decline of plasma HIV RNA in patients treated with antiretroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.

Original languageEnglish
Pages (from-to)528-532
Number of pages5
JournalImmunology Today
Issue number11
StatePublished - 1 Nov 1998


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