HIV infection: How effective is drug combination treatment?

Zvi Grossman; Mark Feinberg; Vladimir Kuznetsov; Dimiter Dimitrov; William Paul

doi:10.1016/S0167-5699(98)01353-X

HIV infection: How effective is drug combination treatment?

Zvi Grossman^*, Mark Feinberg, Vladimir Kuznetsov, Dimiter Dimitrov, William Paul

^*Corresponding author for this work

Physiology Pharmacology

National Institutes of Health

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

The rate of decline of plasma HIV RNA in patients treated with antiretroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.

Original language	English
Pages (from-to)	528-532
Number of pages	5
Journal	Immunology Today
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/S0167-5699(98)01353-X
State	Published - 1 Nov 1998

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10.1016/S0167-5699(98)01353-X

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HIV infection: How effective is drug combination treatment?

Abstract

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