TY - JOUR
T1 - Histopathological study of the human submandibular gland in graft versus host disease
AU - Nagler, R. M.
AU - Sherman, Y.
AU - Nagler, A.
PY - 1999
Y1 - 1999
N2 - Major salivary gland dysfunction and severe xerostomia is one of the manifestations of graft versus host disease (GVHD). The histopathological evaluation of the major salivary gland in patients with GVHD has never been reported. The pathological findings of the submandibular glands in a GVHD patient who succumbed to the disease are described. Lymphocytic infiltration, parenchymal destruction, and fibrosis were observed, which may provide the pathophysiological mechanism for the xerostomia and hyposalivation observed in GVHD.
AB - Major salivary gland dysfunction and severe xerostomia is one of the manifestations of graft versus host disease (GVHD). The histopathological evaluation of the major salivary gland in patients with GVHD has never been reported. The pathological findings of the submandibular glands in a GVHD patient who succumbed to the disease are described. Lymphocytic infiltration, parenchymal destruction, and fibrosis were observed, which may provide the pathophysiological mechanism for the xerostomia and hyposalivation observed in GVHD.
KW - Graft versus host disease
KW - Lymphocyte infiltration
KW - Parenchymal destruction
KW - Submandibular salivary gland
UR - http://www.scopus.com/inward/record.url?scp=0032955568&partnerID=8YFLogxK
U2 - 10.1136/jcp.52.5.395
DO - 10.1136/jcp.52.5.395
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C2 - 10560366
AN - SCOPUS:0032955568
SN - 0021-9746
VL - 52
SP - 395
EP - 397
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
IS - 5
ER -