Histopathologic evaluation of stromal inflammation in Acanthamoeba keratitis

I. Kremer, E. J. Cohen*, R. C. Eagle, I. Udell, P. R. Laibson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Ten corneal specimens obtained at the time of penetrating keratoplasty for long-standing refractory Acanthamoeba keratitis were reviewed. Histopathologic findings included epithelial denudation and variable degrees of necrosis, inflammation, and cysts or trophozoites of acanthamoeba in the stroma. No blood vessels were found in the stroma despite the presence of long-standing corneal inflammation. The absence of corneal stromal neovascularization on biomicroscopic and histopathologic examination is a sign of Acanthamoeba keratitis.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalCLAO Journal
Issue number1
StatePublished - 1994
Externally publishedYes


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