TY - JOUR
T1 - Histological chorioamnionitis at term according to labor onset
T2 - a prospective controlled study
AU - Ganer Herman, Hadas
AU - Schreiber, Letizia
AU - Miremberg, Hadas
AU - Ben Zvi, Masha
AU - Bar, Jacob
AU - Kovo, Michal
N1 - Publisher Copyright:
© 2019, Springer Nature America, Inc.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Objective: To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset. Study design: During 2013–6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries. Results: A total of 260 placentas were obtained, 65 from each group. Rates of HCA for the spontaneous labor, PROM, induction and CD groups were: 49, 32, 24 and 4%, respectively (p < 0.001). Composite neonatal outcome was non-significant between the study groups, and between cases with and without HCA. In a logistic regression model, after controlling for parity - gestational age, mode of delivery, ROM > 12 h and spontaneous onset of labor were found to be independent risk factors for HCA. Conclusion: HCA at term is prevalent in spontaneous labor and supports the association between the inflammatory processes and activation of the physiological signals of parturition.
AB - Objective: To study the incidence of histological chorioamnionitis (HCA) in term pregnancies according to labor onset. Study design: During 2013–6, term pregnancy placentas were prospectively sent to histopathology evaluation, and compared between patients with spontaneous onset labor, pre-labor ROM, labor induction and elective cesarean deliveries. Results: A total of 260 placentas were obtained, 65 from each group. Rates of HCA for the spontaneous labor, PROM, induction and CD groups were: 49, 32, 24 and 4%, respectively (p < 0.001). Composite neonatal outcome was non-significant between the study groups, and between cases with and without HCA. In a logistic regression model, after controlling for parity - gestational age, mode of delivery, ROM > 12 h and spontaneous onset of labor were found to be independent risk factors for HCA. Conclusion: HCA at term is prevalent in spontaneous labor and supports the association between the inflammatory processes and activation of the physiological signals of parturition.
UR - http://www.scopus.com/inward/record.url?scp=85061198070&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0327-8
DO - 10.1038/s41372-019-0327-8
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C2 - 30723280
AN - SCOPUS:85061198070
SN - 0743-8346
VL - 39
SP - 581
EP - 587
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -