Histological and histomorphometrical evaluation of a new implant macrogeometry. A sheep study

Sergio Alexandre Gehrke, Margherita Tumedei, Jaime Aramburú Júnior, Tiago Luis Eirles Treichel, Roni Kolerman, Stefania Lepore, Adriano Piattelli, Giovanna Iezzi

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Decompression or healing chambers between the threads have been proposed to improve and accelerate the osseointegration process of dental implants. The aim of the present work was to test, in an in vivo sheep study, if healing chambers between the threads could produce a better osseointegration process. Thirty titanium implants (15 conventional design (control) and 15 implants with healing chambers (test)) were inserted in a random fashion in the tibia of 3 sheep. The animals were euthanized after 30 days of healing, and the retrieved specimens treated to obtain thin ground sections. Histological observations showed that the quantity of newly formed bone growing in an apical direction was lower in the control group (1095 µm) when compared to the Test group (1658 µm). This difference was statistically significant. Moreover, a layer of osteogenic matrix was present around the portion of implants immersed in the marrow spaces. This osteogenic tissue was thicker in the test group. In conclusion, the present study confirmed the very good results in implants with healing chambers that presented a higher percentage of new bone formation.

Original languageEnglish
Article number3477
JournalInternational Journal of Environmental Research and Public Health
Issue number10
StatePublished - 2 May 2020


  • Dental implants
  • Healing chamber
  • Osseointegration
  • Osteogenic matrix


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