@article{050892441caf46a69bdb106f2e2935c5,
title = "Hippocampal cell nuclear binding of corticosterone following 5,7-dihydroxytryptamine",
abstract = "Adult male rats were injected into the lateral brain ventricle with 5,7-dihydroxytryptainine (5,7-DHT). They were adrenalectomized 5-7 days later and, following an additional 24 h, the specific in vitro [3H]corticosterone binding capacity of dorsal hippocampal slices was determined by estimation of uptake of radioactivity by the nuclear fraction. Specific corticosterone (CS) binding was reduced by 50-70% in the neurotoxin-treated as compared to vehicle-injected animals. Brain serotonin and 5-hydroxyindoleacetic acid concentrations were depleted by 50-70% in the 5,7-DHT-injected rats. These results suggest that the maintenance of normal dorsal hippocampal CS binding capacity is dependent upon the integrity of endogenous brain serotoninergic neuronal systems.",
keywords = "5,7-dihydroxytryptamine, corticosterone, hippocampus, nuclear binding, serotonin",
author = "Siegel, {Richard A.} and Joseph Weidenfeld and Meir Chen and Shaul Feldman and Eldad Melamed and Israel Chowers",
note = "Funding Information: * Partially supported by the Israel Academy of Sciences and Humanities. l * To whom correspondence should be addressed: Department of Neurology, Hadassab University Hospital, Ein Karem, Jerusalem (Israel).",
year = "1983",
month = aug,
doi = "10.1016/0303-7207(83)90152-1",
language = "אנגלית",
volume = "31",
pages = "253--259",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "2-3",
}