Hippocampal cell nuclear binding of corticosterone following 5,7-dihydroxytryptamine

Richard A. Siegel, Joseph Weidenfeld*, Meir Chen, Shaul Feldman, Eldad Melamed, Israel Chowers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Adult male rats were injected into the lateral brain ventricle with 5,7-dihydroxytryptainine (5,7-DHT). They were adrenalectomized 5-7 days later and, following an additional 24 h, the specific in vitro [3H]corticosterone binding capacity of dorsal hippocampal slices was determined by estimation of uptake of radioactivity by the nuclear fraction. Specific corticosterone (CS) binding was reduced by 50-70% in the neurotoxin-treated as compared to vehicle-injected animals. Brain serotonin and 5-hydroxyindoleacetic acid concentrations were depleted by 50-70% in the 5,7-DHT-injected rats. These results suggest that the maintenance of normal dorsal hippocampal CS binding capacity is dependent upon the integrity of endogenous brain serotoninergic neuronal systems.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalMolecular and Cellular Endocrinology
Issue number2-3
StatePublished - Aug 1983
Externally publishedYes


FundersFunder number
Israel Academy of Sciences and Humanities


    • 5,7-dihydroxytryptamine
    • corticosterone
    • hippocampus
    • nuclear binding
    • serotonin


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