@article{2fd6dfdbb0054d9bbd19127ace0cf116,
title = "Hippocampal γ-aminobutyric acid and benzodiazepine receptors after early phenobarbital exposure",
abstract = "Mice were exposed to phenobarbital (PhB) prenatally (PreB offspring) by feeding their mothers 3 g/kg PhB in milled food on gestation days 9-18, or neonatally by directly injecting pups of intact mothers with daily dose of 50 mg PhB on postnatal days 2-21 (NeoB offspring). At age 22 or 50 days, the offspring were tested for γ-aminobutyric acid (GABA) up take in the hippocampus and in the rest of the brain. In addition, [3H]muscimol and [3H]flunitrazepam binding in the hippocampus and cortex were measured in the offspring at age 22 and 50 days. Long-term decrease in GABA uptake was found in the NeoB group. A 23% decrease was found in 22-day-old mice (P < 0.001) and a 22% decrease in 50-day-old mice (P < 0.05). In addition, there was a 22% decrease in GABA uptake in the brain of 22-day-old PreB mice (P < 0.05). An increase of 52% in [3H]muscimol binding (P < 0.001) and 45% (P < 0.001) in [3H]flunitrazepam binding were measured in the hippocampus in the 22-day-old NeoB mice; no differences were found in affinity. The differences were short-term and could no longer be detected at age 50 days. No differences were found in the cortex; unlike NeoB, PreB mice did not differ from controls. The results suggest upregulation of the GABAergic system in early PhB exposed mice.",
keywords = "Benzodiazepine receptor, Early exposure, Hippocampus, Phenobarbital, γ-Aminobutyric acid receptor, γ-Aminobutyric acid uptake",
author = "Pick, {Chaim G.} and Abraham Weizman and Fuad Fares and Moshe Gavish and Kanner, {Baruch I.} and Joseph Yanai",
note = "Funding Information: Acknowledgements. Supported by USPHS Grant DA-667(l and by a grant from The Israeli Anti Drug Authority.",
year = "1993",
month = jul,
day = "16",
doi = "10.1016/0165-3806(93)90089-S",
language = "אנגלית",
volume = "74",
pages = "111--116",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier B.V.",
number = "1",
}