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HIPK2 modulates p53 activity towards pro-apoptotic transcription
Rosa Puca
, Lavinia Nardinocchi
, Ada Sacchi
,
Gideon Rechavi
, David Givol
, Gabriella D'Orazi
*
*
Corresponding author for this work
IRCCS Istituti fisioterapici ospitalieri - Istituto Regina Elena
Gabriele d'Annunzio University
Sheba Medical Center at Tel Hashomer
Weizmann Institute of Science
Research output
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Contribution to journal
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Article
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peer-review
82
Scopus citations
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Keyphrases
P53 Activity
100%
Homeodomain-interacting Protein Kinase 2 (HIPK2)
100%
Pro-apoptotic
100%
Lysine
60%
P300
60%
P53 Acetylation
50%
Acetylation
40%
Sirtuin 1 (SIRT1)
40%
Phosphorylation
30%
Knockdown
30%
Drug Response
30%
Overexpression
20%
Transcriptional Activity
20%
Zinc
20%
Apoptotic Activity
20%
Deacetylase Inhibitor
20%
RNA Interference
10%
Gene Transcription
10%
Post-translational Modification
10%
Stress-induced
10%
Chemotherapy
10%
C-terminus
10%
Tumor
10%
In Cancer
10%
Cellular Response
10%
Histone Deacetylase Inhibitor (HDACi)
10%
Cancer Cells
10%
DNA Damage
10%
Adriamycin
10%
Chromatin Immunoprecipitation (ChIP)
10%
Nicotinamide
10%
Deacetylase
10%
P53 Transcriptional Activity
10%
P53 Protein
10%
Oncosuppressor
10%
Trichostatin A
10%
Combination Strategy
10%
Histone Deacetylase 1 (HDAC1)
10%
Deacetylase Activity
10%
Pharmacological Agents
10%
Natural Agents
10%
Biochemistry, Genetics and Molecular Biology
Transcription
100%
Protein Kinases
100%
Homeodomain
100%
P53
100%
Acetylation
35%
Lysine
30%
Serine
25%
Promoter Region
10%
Deacetylation
10%
Cancer Cell
5%
Posttranslational Modification
5%
DNA Damage Response
5%
Chromatin Immunoprecipitation
5%
Zinc
5%
RNA Interference
5%
Genetic Transcription
5%
C-Terminus
5%
Histone Deacetylase
5%
Trichostatin A
5%
Doxorubicin
5%
Nicotinamide
5%
Neuroscience
P53
100%
Homeodomain Interacting Protein Kinase 2
100%
Acetylation
35%
Lysine
30%
Serine
25%
Promoter Region
10%
Genetic Transcription
5%
In Vivo
5%
Nicotinamide
5%
DNA Damage Response
5%
Posttranslational Modification
5%
C-Terminus
5%
Immunoprecipitation
5%
Histone Deacetylase
5%
Trichostatin A
5%
RNA Silencing
5%
Doxorubicin
5%
Pharmacology, Toxicology and Pharmaceutical Science
Protein P53
100%
Homeodomain Interacting Protein Kinase 2
100%
Lysine
30%
Serine
25%
Small Interfering RNA
5%
Malignant Neoplasm
5%
Chemotherapy
5%
Neoplasm
5%
Doxorubicin
5%
Nicotinamide
5%
Trichostatin A
5%
Chromatin Immunoprecipitation
5%
Histone Deacetylase
5%