Highway or byway: the metabolic role of the GABA shunt in plants

Aaron Fait, Hillel Fromm, Dirk Walter, Gad Galili, Alisdair R. Fernie

Research output: Contribution to journalArticlepeer-review


Much of the recent work on the γ-aminobutyrate (GABA) shunt in plants has concentrated on stress/pest-associated and signalling roles. However, fifty years after the structural elucidation of the pathway, aspects of its regulation and even of its biological significance remain largely obscure. Here, we assess the importance of GABA metabolism in plants, reviewing relevant biological circumstances and taking advantage of high-throughput data accessibility and computational approaches. We discuss the premise that GABA metabolism plays a major role in carbon and nitrogen primary metabolism. We further evaluate technological developments that will likely allow us to address the quantitative importance of this shunt within the biological processes to which it contributes.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalTrends in Plant Science
Issue number1
StatePublished - Jan 2008


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