High-throughput sequencing to decipher the genetic heterogeneity of deafness

Zippora Brownstein, Yoni Bhonker, Karen B. Avraham*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Identifying genes causing non-syndromic hearing loss has been challenging using traditional approaches. We describe the impact that high-throughput sequencing approaches are having in discovery of genes related to hearing loss and the implications for clinical diagnosis.

Original languageEnglish
Article number245
JournalGenome Biology
Volume13
Issue number5
DOIs
StatePublished - 29 May 2012

Funding

FundersFunder number
Hedrich Charitable Trust
National Institutes of Health
National Institute on Deafness and Other Communication Disorders41/11, R01DC011835

    Keywords

    • Deep sequencing
    • Exome sequencing
    • Genomics
    • Hearing loss
    • Homozygosity mapping
    • Massive parallel sequencing
    • Next-generation sequencing

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