TY - JOUR
T1 - High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis
AU - Penn, Moran
AU - Mausner-Fainberg, Karin
AU - Golan, Maya
AU - Karni, Arnon
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/9/15
Y1 - 2017/9/15
N2 - Blockage of bone morphogenetic protein (BMP) signaling is required for differentiation of neurons and oligodendrocytes from neural stem cells (NSCs). Sera of untreated relapsing-remitting multiple sclerosis (RR-MS) patients expressed significantly higher levels of BMP-2 compared to sera of healthy controls. BMP-2 levels correlated with BMP-4 and -5 levels only in sera of untreated MS patients. Furthermore, sera of untreated patients inhibited the neuronal differentiation of RA-treated P19 cells, which was associated with induction of phospho-SMAD signaling pathway. These results suggest that BMP-2 sera levels may play a role in the failure of remyelination and neuro-regeneration in RR-MS.
AB - Blockage of bone morphogenetic protein (BMP) signaling is required for differentiation of neurons and oligodendrocytes from neural stem cells (NSCs). Sera of untreated relapsing-remitting multiple sclerosis (RR-MS) patients expressed significantly higher levels of BMP-2 compared to sera of healthy controls. BMP-2 levels correlated with BMP-4 and -5 levels only in sera of untreated MS patients. Furthermore, sera of untreated patients inhibited the neuronal differentiation of RA-treated P19 cells, which was associated with induction of phospho-SMAD signaling pathway. These results suggest that BMP-2 sera levels may play a role in the failure of remyelination and neuro-regeneration in RR-MS.
KW - Bone morphogenetic proteins (BMPs)
KW - Multiple sclerosis
KW - Neural stem cells (NSCs)
KW - Neurogenesis
KW - P19 cells
UR - http://www.scopus.com/inward/record.url?scp=85024899159&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2017.07.008
DO - 10.1016/j.jneuroim.2017.07.008
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C2 - 28778435
AN - SCOPUS:85024899159
SN - 0165-5728
VL - 310
SP - 120
EP - 128
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -