High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis

Moran Penn, Karin Mausner-Fainberg, Maya Golan, Arnon Karni

Research output: Contribution to journalArticlepeer-review

Abstract

Blockage of bone morphogenetic protein (BMP) signaling is required for differentiation of neurons and oligodendrocytes from neural stem cells (NSCs). Sera of untreated relapsing-remitting multiple sclerosis (RR-MS) patients expressed significantly higher levels of BMP-2 compared to sera of healthy controls. BMP-2 levels correlated with BMP-4 and -5 levels only in sera of untreated MS patients. Furthermore, sera of untreated patients inhibited the neuronal differentiation of RA-treated P19 cells, which was associated with induction of phospho-SMAD signaling pathway. These results suggest that BMP-2 sera levels may play a role in the failure of remyelination and neuro-regeneration in RR-MS.

Original languageEnglish
Pages (from-to)120-128
Number of pages9
JournalJournal of Neuroimmunology
Volume310
DOIs
StatePublished - 15 Sep 2017

Keywords

  • Bone morphogenetic proteins (BMPs)
  • Multiple sclerosis
  • Neural stem cells (NSCs)
  • Neurogenesis
  • P19 cells

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