High-resolution STM imaging of novel single G4-DNA molecules

Errez Shapir, Lior Sagiv, Natalia Borovok, Tatiana Molotski, Alexander B. Kotlyar, Danny Porath

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The molecular morphology of long G4-DNA wires made by a novel synthetic method was, for the first time, characterized by high-resolution scanning tunneling microscopy (STM). The STM images reveal a periodic structure seen as repeating "bulbs" along the molecules. These bulbs reflect the helix morphology of the wires. The STM measurements were supported by a statistical morphology analysis of the DNA pitch length and apparent height relative to the surface. In the absence of X-ray and NMR data for these wires, the STM measurements provide a unique alternative to characterize the helix morphology.

Original languageEnglish
Pages (from-to)9267-9269
Number of pages3
JournalJournal of Physical Chemistry B
Issue number31
StatePublished - 7 Aug 2008


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