High-resolution scanning tunneling microscopy imaging of biotin-avidin-G4-DNA molecules

Iris Roger-Eitan, Ke Liu, Gideon I. Livshits, Natalia Borovok, Dvir Rotem, Alexander B. Kotlyar, Danny Porath

Research output: Contribution to journalArticlepeer-review

Abstract

The morphological structure of G4-DNA wires having four parallel strands, made by a novel synthesis method, was revealed by high-resolution scanning tunneling microscopy (STM). This imaging technique is a unique alternative to obtain information on the molecular structure of these wires in the absence of X-ray and NMR data. Imaging reveals a periodic structure seen as repeating "bulbs" along the molecule. The bulbs correspond to the helical structure of the molecules. The STM imaging shows a molecular chain structure. This structure exhibits an average periodicity of 3.5 nm and an average molecular apparent height of 1.4 nm.

Original languageEnglish
Pages (from-to)22462-22465
Number of pages4
JournalJournal of Physical Chemistry C
Volume117
Issue number43
DOIs
StatePublished - 31 Oct 2013

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