High-resolution HLA A∼B∼DRB1 haplotype frequencies from the Ezer Mizion Bone Marrow Donor Registry in Israel

Sigal Manor*, Michael Halagan, Nira Shriki, Isaac Yaniv, Bracha Zisser, Martin Maiers, Abeer Madbouly, Jerry Stein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated HLA population alleles and haplotype frequencies for the ethnicities that comprise the contemporary population of Israel, using a large data set from the Ezer Mizion Bone Barrow Donor Registry. We genotyped 275,699 individuals at the HLA-A, -B and -DRB1 loci using HLA genotyping methods. HLA A∼B∼DRB1 haplotype frequencies were estimated from 19 sub-ethnic Jewish populations and other non-Jewish minorities using the maximum likelihood model, which accommodates typing ambiguities. We present overall and sub-ethnicity specific HLA diversity results of the registry, which will help guide a data-driven strategy for future registry expansion.

Original languageEnglish
Pages (from-to)1114-1119
Number of pages6
JournalHuman Immunology
Volume77
Issue number12
DOIs
StatePublished - 1 Dec 2016

Keywords

  • Bone marrow donor registry
  • HLA
  • Haplotype and allele frequencies
  • Jewish population

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