High-quality embryos retain their implantation capability in overweight women

Jacob Farhi*, Avi Ben-Haroush, Onit Sapir, Benjamin Fisch, Jacob Ashkenazi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the effect of obesity on implantation rate, pregnancy rate and course of pregnancy in young women undergoing IVF in whom only high-quality embryos were transferred, a cohort study included women attending the IVF unit in 2006-2007 with favourable parameters to achieve pregnancy (<38 years, fewer than three IVF cycles, transfer of two high-quality embryos), grouped by body mass index (BMI). Of 230 women, 160 had a BMI ≤25 kg/m2 (mean 21.6 ± 2.2) and 73 had BMI >25 kg/m2 (mean 29.5 ± 3.7). The overweight group had a higher consumption of gonadotrophins during stimulation. There were no between-group differences in treatment protocols, duration of gonadotrophin stimulation, maximal oestradiol concentrations, endometrial thickness and number of oocytes retrieved/fertilized, or in rates of pregnancy (51.3%, 52.1%), implantation (34.5%, 37.5%), multiple pregnancy, and abortion. Rate of gestational diabetes or pregnancy-induced hypertension was higher in the overweight group (23.3%, 8.2%; P = 0.045). Within the overweight group, those with multiple pregnancies were at highest risk (31.3%, 6.9%; P = 0.031). In conclusion, implantation and pregnancy rates are not compromised in overweight women when high-quality embryos are transferred. However, in overweight women, pregnancy complications remain high, mainly in those with multiple pregnancies.

Original languageEnglish
Pages (from-to)706-711
Number of pages6
JournalReproductive BioMedicine Online
Volume21
Issue number5
DOIs
StatePublished - Nov 2010

Keywords

  • BMI
  • IVF
  • implantation
  • overweight
  • pregnancy complications

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