High Pressure Liquid Chromatographic Microassay for Simultaneous Measurement of Doxapram and Its Metabolites in Premature Newborn Infants

J. V. Aranda, K. Beharry, J. Rex, N. Linder, P. Blanchard

Research output: Contribution to journalArticlepeer-review

Abstract

A simple, specific, rapid and sensitive high pressure liquid chromatographic microassay is described for the simultaneous measurement of doxapram and its metabolites. Doxapram appears rapidly metabolized to ketodoxapram in premature newborn infants with apnea. Therapeutic drug monitoring for doxapram and its metabolites appears warranted during doxapram therapy of neonatal apnea.

Original languageEnglish
Pages (from-to)2983-2991
Number of pages9
JournalJournal of Liquid Chromatography
Volume11
Issue number14
DOIs
StatePublished - 1 Oct 1988
Externally publishedYes

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