High levels of catecholamines in human semen: A preliminary study

G. Fait, Y. Vered, L. Yogev, R. Gamzu, J. B. Lessing, G. Paz, H. Yavetz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The objective of this study was to determine the seminal concentrations of four different catecholamines and their association with semen quality. Seminal concentrations of adrenaline, noradrenaline, 3,4-dihydroxy-phenyl-alanine (DOPA), and 3,4-dihydroxy-phenyl acetic acid (DOPAC) were determined in 13 healthy volunteers, using high-performance liquid chromatography with an electrochemical detector. In addition, semen analysis was performed. Noradrenaline and DOPA were present in all specimens with a concentration of 15 181 ± 2951 pg ml-1 and 4023 ± 429 pg ml-1 (mean ± SE), respectively. These concentrations are respectively 19 times (range: 3-44) and twice (range: 1-3) as high as the maximal normal concentration in plasma. Adrenaline was present in 10 and DOPAC in seven of 13 specimens. No correlation was found between the concentration of any of the catecholamines evaluated and semen characteristics. In conclusion, noradrenaline and DOPA are present in human semen at concentrations that are much higher than maximal normal values in plasma. Adrenaline and DOPAC were also found in some of the samples. The concentrations of catecholamines in semen are not associated with semen quality.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
Issue number6
StatePublished - 2001
Externally publishedYes


  • Catecholamines
  • Semen


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