High levels of a common anti-DNA idiotype (16/6), a genetic marker for SLE

Y. Shoenfeld, S. Brill, A. Weinberger, J. Pinkhas, D. A. Isenberg

Research output: Contribution to journalArticlepeer-review

Abstract

Six out of 8 healthy first-degree relatives of a patient with systemic lupus erythematosus (SLE) had very high serum levels of a common anti-DNA idiotype (16/6). In this family an additional sister developed SLE, and all members were heterozygous for C4 deficiency. Measurements of common autoantibody idiotypes may contribute to the understanding of the genetics of autoimmune diseases. They might be found useful in detecting healthy subjects prone to the development of an overt clinical state.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalActa Haematologica
Volume76
Issue number2-3
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Dive into the research topics of 'High levels of a common anti-DNA idiotype (16/6), a genetic marker for SLE'. Together they form a unique fingerprint.

Cite this