High frequency of MGUS in DSP

Alon Abraham, Carolina Barnett, Hans D. Katzberg, Leif E. Lovblom, Bruce A. Perkins, Vera Bril

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP). Methods: Patients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between November 2008 and December 2013. Results: Fifty controls, 66 patients with DM 1, and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. In patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively. Discussion: DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57: 1018–1021, 2018.

Original languageEnglish
Pages (from-to)1018-1021
Number of pages4
JournalMuscle and Nerve
Volume57
Issue number6
DOIs
StatePublished - Jun 2018

Keywords

  • diabetic polyneuropathy
  • HbA1c
  • monoclonal gammopathy
  • sural nerve action potential amplitude
  • type 1 DM
  • type 2 DM

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