High frequency of MGUS in DSP

Alon Abraham; Carolina Barnett; Hans D. Katzberg; Leif E. Lovblom; Bruce A. Perkins; Vera Bril

doi:10.1002/mus.26054

High frequency of MGUS in DSP

Alon Abraham, Carolina Barnett, Hans D. Katzberg, Leif E. Lovblom, Bruce A. Perkins, Vera Bril

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP). Methods: Patients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between November 2008 and December 2013. Results: Fifty controls, 66 patients with DM 1, and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. In patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively. Discussion: DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57: 1018–1021, 2018.

Original language	English
Pages (from-to)	1018-1021
Number of pages	4
Journal	Muscle and Nerve
Volume	57
Issue number	6
DOIs	https://doi.org/10.1002/mus.26054
State	Published - Jun 2018

Keywords

diabetic polyneuropathy
HbA1c
monoclonal gammopathy
sural nerve action potential amplitude
type 1 DM
type 2 DM

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10.1002/mus.26054

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title = "High frequency of MGUS in DSP",

abstract = "Introduction: Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP). Methods: Patients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between November 2008 and December 2013. Results: Fifty controls, 66 patients with DM 1, and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. In patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively. Discussion: DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57: 1018–1021, 2018.",

keywords = "diabetic polyneuropathy, HbA1c, monoclonal gammopathy, sural nerve action potential amplitude, type 1 DM, type 2 DM",

author = "Alon Abraham and Carolina Barnett and Katzberg, {Hans D.} and Lovblom, {Leif E.} and Perkins, {Bruce A.} and Vera Bril",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2018",

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doi = "10.1002/mus.26054",

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volume = "57",

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AU - Abraham, Alon

AU - Barnett, Carolina

AU - Katzberg, Hans D.

AU - Lovblom, Leif E.

AU - Perkins, Bruce A.

AU - Bril, Vera

PY - 2018/6

Y1 - 2018/6

N2 - Introduction: Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP). Methods: Patients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between November 2008 and December 2013. Results: Fifty controls, 66 patients with DM 1, and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. In patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively. Discussion: DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57: 1018–1021, 2018.

AB - Introduction: Monoclonal gammopathy has been reported in several polyneuropathies. In this study, we sought to explore the frequency and characteristics of monoclonal gammopathy in patients with diabetic sensorimotor polyneuropathy (DSP). Methods: Patients with type 1 and type 2 diabetes mellitus (DM 1, DM 2) and controls without diabetes were evaluated between November 2008 and December 2013. Results: Fifty controls, 66 patients with DM 1, and 106 patients with DM 2 were included, with average ages of 43 ± 18, 45 ± 17, and 65 ± 10 years, respectively; the frequency of monoclonal gammopathy was 0%, 8%, and 15%, respectively. In patients with DSP, the frequency of monoclonal gammopathy increased to 14% in DM 1 and 21% in DM 2; the most common monoclonal proteins were immunoglobulin (Ig) M and IgG, respectively. Discussion: DSP might be associated with a high frequency of monoclonal gammopathy, with different characteristics in DM 1 and in DM 2. Muscle Nerve 57: 1018–1021, 2018.

KW - diabetic polyneuropathy

KW - HbA1c

KW - monoclonal gammopathy

KW - sural nerve action potential amplitude

KW - type 1 DM

KW - type 2 DM

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SN - 0148-639X

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High frequency of MGUS in DSP

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