TY - JOUR
T1 - High frequency of loss of heterozygosity for 1p35-p36 (D1S247) in Wilms tumor
AU - Steinberg, Ran
AU - Freud, Enrique
AU - Zer, Michael
AU - Ziperman, Izolda
AU - Goshen, Yacov
AU - Ash, Shifra
AU - Stein, Jeremiah
AU - Zaizov, Rina
AU - Avigad, Smadar
PY - 2000/3
Y1 - 2000/3
N2 - We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor. (C) Elsevier Science Inc., 2000.
AB - We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor. (C) Elsevier Science Inc., 2000.
UR - http://www.scopus.com/inward/record.url?scp=0033994192&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(99)00165-X
DO - 10.1016/S0165-4608(99)00165-X
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AN - SCOPUS:0033994192
VL - 117
SP - 136
EP - 139
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -
