High frequency of loss of heterozygosity for 1p35-p36 (D1S247) in Wilms tumor

Ran Steinberg, Enrique Freud, Michael Zer, Izolda Ziperman, Yacov Goshen, Shifra Ash, Jeremiah Stein, Rina Zaizov, Smadar Avigad

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor. (C) Elsevier Science Inc., 2000.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume117
Issue number2
DOIs
StatePublished - Mar 2000
Externally publishedYes

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