High Familial Correlation in Methylphenidate Response and Side Effect Profile

Michal Gazer-Snitovsky; Ayelet Brand-Gothelf; Gal Dubnov-Raz; Abraham Weizman; Doron Gothelf

doi:10.1177/1087054715580844

High Familial Correlation in Methylphenidate Response and Side Effect Profile

Michal Gazer-Snitovsky, Ayelet Brand-Gothelf, Gal Dubnov-Raz, Abraham Weizman, Doron Gothelf^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective: To examine whether a familial tendency exists in clinical response to methylphenidate. Method: Nineteen pairs of siblings or parent–child stimulant-naive individuals with ADHD were prescribed methylphenidate–immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale. Results: We found significant intraclass correlations in family member response to methylphenidate–immediate release and side effect profile, including emotional symptoms and loss of appetite and weight. Conclusion: Family history of response to methylphenidate should be taken into account when treating ADHD.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Journal of Attention Disorders
Volume	23
Issue number	2
DOIs	https://doi.org/10.1177/1087054715580844
State	Published - 1 Jan 2019

Funding

Funders	Funder number
Ariana and Alexander Katz
Sackler Faculty of Medicine, Tel Aviv University

Keywords

ADHD
familial
methylphenidate
response
side effects

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10.1177/1087054715580844

Cite this

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AB - Objective: To examine whether a familial tendency exists in clinical response to methylphenidate. Method: Nineteen pairs of siblings or parent–child stimulant-naive individuals with ADHD were prescribed methylphenidate–immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale. Results: We found significant intraclass correlations in family member response to methylphenidate–immediate release and side effect profile, including emotional symptoms and loss of appetite and weight. Conclusion: Family history of response to methylphenidate should be taken into account when treating ADHD.

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High Familial Correlation in Methylphenidate Response and Side Effect Profile

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