High factor VIII as a risk factor for venous thrombosis

K. Elishkewitch*, S. Berliner, A. Eldor, I. Shapira

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Several studies have shown that increased concentrations of factor VIII are associated with thrombophilia. It has been also shown that this is not an acute phase response pattern, and that these individuals have increased factor VIII concentrations due to genetic and environmental causes. Part of the thrombophilic pattern might be related to an acquired Activated Protein C resistance condition. Since individuals with venous thromboembolism and increased factor VIII concentrations present a high recurrence rate, the determination of factor VIII concentrations should be included in the laboratory thrombophilia screening work-up.

Original languageEnglish
Pages (from-to)1122-1124, 1232
Issue number12
StatePublished - Dec 2001


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