High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia

Elena Vendramini; Marco Giordan; Emanuela Giarin; Barbara Michielotto; Grazia Fazio; Gianni Cazzaniga; Andrea Biondi; Daniela Silvestri; Maria Grazia Valsecchi; Martina U. Muckenthaler; Andreas E. Kulozik; Valter Gattei; Shai Izraeli; Giuseppe Basso; Geertruy te Kronnie

doi:10.18632/oncotarget.16392

High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia

Elena Vendramini^*, Marco Giordan, Emanuela Giarin, Barbara Michielotto, Grazia Fazio, Gianni Cazzaniga, Andrea Biondi, Daniela Silvestri, Maria Grazia Valsecchi, Martina U. Muckenthaler, Andreas E. Kulozik, Valter Gattei, Shai Izraeli, Giuseppe Basso, Geertruy te Kronnie

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations. We describe clinical and genomic features of the ERG-related cases in an unselected cohort of B-other BCP ALL pediatric patients enrolled in the AIEOP ALL 2000 therapeutic protocol. We report a small noncoding RNA signature specific of ERG-related group, with up-regulation of miR-125b-2 cluster on chromosome 21 and several snoRNAs in the Prader-Willi locus at 15q11.2, including the orphan SNORD116 cluster.

Original language	English
Pages (from-to)	42398-42413
Number of pages	16
Journal	Oncotarget
Volume	8
Issue number	26
DOIs	https://doi.org/10.18632/oncotarget.16392
State	Published - 2017

Funding

Funders	Funder number
Seventh Framework Programme	261474

Keywords

B cell precursor acute lymphoblastic leukemia
ERG aberrations
MiR-125
Noncoding RNAs
SNORD116

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.16392

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Vendramini, E., Giordan, M., Giarin, E., Michielotto, B., Fazio, G., Cazzaniga, G., Biondi, A., Silvestri, D., Valsecchi, M. G., Muckenthaler, M. U., Kulozik, A. E., Gattei, V., Izraeli, S., Basso, G., & Kronnie, G. T. (2017). High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia. Oncotarget, 8(26), 42398-42413. https://doi.org/10.18632/oncotarget.16392

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title = "High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia",

abstract = "ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations. We describe clinical and genomic features of the ERG-related cases in an unselected cohort of B-other BCP ALL pediatric patients enrolled in the AIEOP ALL 2000 therapeutic protocol. We report a small noncoding RNA signature specific of ERG-related group, with up-regulation of miR-125b-2 cluster on chromosome 21 and several snoRNAs in the Prader-Willi locus at 15q11.2, including the orphan SNORD116 cluster.",

keywords = "B cell precursor acute lymphoblastic leukemia, ERG aberrations, MiR-125, Noncoding RNAs, SNORD116",

author = "Elena Vendramini and Marco Giordan and Emanuela Giarin and Barbara Michielotto and Grazia Fazio and Gianni Cazzaniga and Andrea Biondi and Daniela Silvestri and Valsecchi, {Maria Grazia} and Muckenthaler, {Martina U.} and Kulozik, {Andreas E.} and Valter Gattei and Shai Izraeli and Giuseppe Basso and Kronnie, {Geertruy te}",

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year = "2017",

doi = "10.18632/oncotarget.16392",

language = "אנגלית",

volume = "8",

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Vendramini, E, Giordan, M, Giarin, E, Michielotto, B, Fazio, G, Cazzaniga, G, Biondi, A, Silvestri, D, Valsecchi, MG, Muckenthaler, MU, Kulozik, AE, Gattei, V, Izraeli, S, Basso, G & Kronnie, GT 2017, 'High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia', Oncotarget, vol. 8, no. 26, pp. 42398-42413. https://doi.org/10.18632/oncotarget.16392

TY - JOUR

T1 - High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia

AU - Vendramini, Elena

AU - Giordan, Marco

AU - Giarin, Emanuela

AU - Michielotto, Barbara

AU - Fazio, Grazia

AU - Cazzaniga, Gianni

AU - Biondi, Andrea

AU - Silvestri, Daniela

AU - Valsecchi, Maria Grazia

AU - Muckenthaler, Martina U.

AU - Kulozik, Andreas E.

AU - Gattei, Valter

AU - Izraeli, Shai

AU - Basso, Giuseppe

AU - Kronnie, Geertruy te

PY - 2017

Y1 - 2017

N2 - ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations. We describe clinical and genomic features of the ERG-related cases in an unselected cohort of B-other BCP ALL pediatric patients enrolled in the AIEOP ALL 2000 therapeutic protocol. We report a small noncoding RNA signature specific of ERG-related group, with up-regulation of miR-125b-2 cluster on chromosome 21 and several snoRNAs in the Prader-Willi locus at 15q11.2, including the orphan SNORD116 cluster.

AB - ERG-related leukemia is a B cell precursor acute lymphoblastic leukemia (BCP ALL) subtype characterized by aberrant expression of DUX4 and ERG transcription factors, and highly recurrent ERG intragenic deletions. ERG-related patients have remarkably favorable outcome despite a high incidence of inauspicious IKZF1 aberrations. We describe clinical and genomic features of the ERG-related cases in an unselected cohort of B-other BCP ALL pediatric patients enrolled in the AIEOP ALL 2000 therapeutic protocol. We report a small noncoding RNA signature specific of ERG-related group, with up-regulation of miR-125b-2 cluster on chromosome 21 and several snoRNAs in the Prader-Willi locus at 15q11.2, including the orphan SNORD116 cluster.

KW - B cell precursor acute lymphoblastic leukemia

KW - ERG aberrations

KW - MiR-125

KW - Noncoding RNAs

KW - SNORD116

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AN - SCOPUS:85021305230

SN - 1949-2553

VL - 8

SP - 42398

EP - 42413

JO - Oncotarget

JF - Oncotarget

IS - 26

ER -

High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia

Abstract

Funding

Keywords

UN SDGs

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