High-dose radiotherapy as neoadjuvant treatment in non-small-cell lung cancer

Aaron M. Allen, Tzippy Shochat, Dov Flex, Mordechai R. Kramer, Alona Zer, Nir Peled, Elizabeta Dudnik, Eyal Fenig, Milton Saute

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Trimodality therapy (chemoradiation followed by surgery) provides a benefit in progression-free survival but not overall survival. We sought to determine if a high dose of radiation could be delivered safely and provide a clinical benefit. Methods: Consecutive patients with stage IIIA or IIIB non-small-cell lung cancer (NSCLC) treated with concurrent chemoradiotherapy followed by surgery were reviewed with IRB approval. Results: A total of 48 patients were treated from November 2007 to May 2014. Of these, 64% had stage IIIA disease while 36% had stage IIIB; 46% had adenocarcinoma, 34% squamous, and 23% NSCLC not otherwise specified. The median dose of chemoradiotherapy was 72 Gy (60-72). Overall, 86% of patients received cisplatin (50 mg/m2) and etoposide (50 mg/m2) concurrently with radiotherapy; 72% of patients underwent lobectomy following chemoradiotherapy and 28% underwent pneumonectomy. The 30- and 90-day mortality rates were 0%. The nodal downstaging rate was 82% and there was a 64% rate of pathologic complete response. The overall survival was 29.9 months (95% CI, 19-86 months). The median time to locoregional progression was 35.1 months and the median time to distant progression was 39.3 months. Locoregional failure was 8% and distant failure was 44%. Conclusion: High-dose preoperative chemoradiotherapy was safe and effective. This combination should be further considered.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalOncology
Volume95
Issue number1
DOIs
StatePublished - 1 Jun 2018

Keywords

  • Lung cancer
  • Neoadjuvant treatment
  • Radiotherapy
  • Surgery

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