TY - JOUR
T1 - High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
AU - Genizi, Jacob
AU - Berger, Lotan
AU - Mahajnah, Muhammad
AU - Shlonsky, Yulia
AU - Golan-Shany, Orit
AU - Romem, Azriel
AU - Halevy, Ayelet
AU - Nathan, Keren
AU - Sharkia, Rajech
AU - Zalan, Abdelnaser
AU - Kessel, Aharon
AU - Cohen, Rony
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/7
Y1 - 2023/7
N2 - Pseudotumor cerebri (PTC) is a disorder characterized by increased intracranial pressure in the absence of a structural lesion or other identifiable cause. Cytokines, which are involved in the regulation of immune responses and inflammation, have been implicated in the pathogenesis of PTC. In a prospective, cross-sectional study at three centers in Israel, we analyzed cerebrospinal fluid (CSF) samples from 60 children aged 0.5–18 years, including 43 children with a definitive diagnosis of PTC and a control group of 17 children. Levels of IL-4, IL-10, IL-17, CCL2, CCL7, CCL8, CCL13, BDNF, and IFN-γ were measured using ELISA kits. Levels of CCL2 were significantly higher in the PTC group compared to the control group (p < 0.05), with no other significant differences in the measured cytokines between the two groups. The groups did not differ significantly in clinical presentation, imaging, treatment, or ophthalmic findings. Our findings provide preliminary evidence that CCL2 may be involved in the pathogenesis of PTC and may serve a potential target for therapy in PTC.
AB - Pseudotumor cerebri (PTC) is a disorder characterized by increased intracranial pressure in the absence of a structural lesion or other identifiable cause. Cytokines, which are involved in the regulation of immune responses and inflammation, have been implicated in the pathogenesis of PTC. In a prospective, cross-sectional study at three centers in Israel, we analyzed cerebrospinal fluid (CSF) samples from 60 children aged 0.5–18 years, including 43 children with a definitive diagnosis of PTC and a control group of 17 children. Levels of IL-4, IL-10, IL-17, CCL2, CCL7, CCL8, CCL13, BDNF, and IFN-γ were measured using ELISA kits. Levels of CCL2 were significantly higher in the PTC group compared to the control group (p < 0.05), with no other significant differences in the measured cytokines between the two groups. The groups did not differ significantly in clinical presentation, imaging, treatment, or ophthalmic findings. Our findings provide preliminary evidence that CCL2 may be involved in the pathogenesis of PTC and may serve a potential target for therapy in PTC.
KW - chemokines
KW - cytokines
KW - etiology
KW - pediatrics
KW - pseudotumor cerebri
UR - http://www.scopus.com/inward/record.url?scp=85166323565&partnerID=8YFLogxK
U2 - 10.3390/children10071122
DO - 10.3390/children10071122
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C2 - 37508619
AN - SCOPUS:85166323565
SN - 2227-9067
VL - 10
JO - Children
JF - Children
IS - 7
M1 - 1122
ER -