High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats

Oded Klavir, Christine Winter, Daphna Joel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, suggesting that HFS of either segment of the globus pallidus may provide an additional therapeutic strategy for OCD.

Original languageEnglish
Pages (from-to)84-93
Number of pages10
JournalBehavioural Brain Research
Volume216
Issue number1
DOIs
StatePublished - 1 Jan 2011

Keywords

  • Animal model
  • Deep brain stimulation (DBS)
  • Extinction
  • Obsessive-compulsive disorder (OCD)
  • Signal attenuation

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