TY - JOUR
T1 - High b value q-space-analyzed diffusion MRI in vascular dementia
T2 - A preliminary study
AU - Assaf, Y.
AU - Mayzel-Oreg, O.
AU - Gigi, A.
AU - Ben-Bashat, D.
AU - Mordohovitch, M.
AU - Verchovsky, R.
AU - Reider-Groswasser, I. I.
AU - Hendler, T.
AU - Graif, M.
AU - Cohen, Y.
AU - Korczyn, A. D.
PY - 2002/11/15
Y1 - 2002/11/15
N2 - High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are very common in VaD as well as in other types of dementia. Therefore, the role of white matter changes in the cognitive and memory decline that occurs in VaD patients is still under debate. High-b DWI, analyzed using the q-space approach, is a more sensitive MRI method for detection of white matter changes. High-b DWI revealed massive white matter loss in VaD patients that surpassed the boundaries of T2 hyperintensities. This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease.
AB - High b value diffusion weighted magnetic resonance imaging (high-b DWI) was used to characterize white matter changes in the brain of patients with vascular dementia (VaD). Hyperintense white matter areas detected by T2-weighted magnetic resonance imaging (MRI) represent lesions, also termed leukoaraiosis that are very common in VaD as well as in other types of dementia. Therefore, the role of white matter changes in the cognitive and memory decline that occurs in VaD patients is still under debate. High-b DWI, analyzed using the q-space approach, is a more sensitive MRI method for detection of white matter changes. High-b DWI revealed massive white matter loss in VaD patients that surpassed the boundaries of T2 hyperintensities. This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease.
KW - Brain imaging
KW - Diffusion
KW - Diffusion-weighted imaging
KW - MRI
KW - Vascular dementia
KW - q-space
UR - http://www.scopus.com/inward/record.url?scp=0037111267&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(02)00297-6
DO - 10.1016/S0022-510X(02)00297-6
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AN - SCOPUS:0037111267
SN - 0022-510X
VL - 203-204
SP - 235
EP - 239
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -