TY - JOUR
T1 - High and low body mass index may predict severe disease course in children with inflammatory bowel disease
AU - Yerushalmy-Feler, Anat
AU - Ben-Tov, Amir
AU - Weintraub, Yael
AU - Amir, Achiya
AU - Galai, Tut
AU - Moran-Lev, Hadar
AU - Cohen, Shlomi
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/6/3
Y1 - 2018/6/3
N2 - Objectives: Inflammatory bowel disease (IBD) has been historically associated with underweight and malnutrition. The impact of both underweight and obesity on the clinical course of IBD in adults is controversial. This study described the association between body mass index (BMI) at diagnosis to disease course in children with IBD. Methods: We reviewed the medical records of children with IBD from the database of the ‘Dana-Dwek’ Children’s Hospital between 2010 and 2016. Demographic and anthropometric data were collected as were disease characteristics, course and therapy. Patients were categorized in quartiles according to BMI percentiles at diagnosis (Q1–Q4). Results: Of 100 children who were identified, 62 had Crohn’s disease (CD) and 38 had ulcerative colitis (UC). The median age (interquartile range, IQR) at diagnosis was 13.7 (range 11.9–15.2) years. The median (IQR) follow-up was 2.1 (1.2–3.8) years. At diagnosis, 46 children (46%) were in Q1, 20 (20%) in Q2, 19 (19%) in Q3 and 15 (15%) in Q4. Prolonged time to diagnosis was associated with BMI in Q1 and Q4, as well as high disease activity at diagnosis (p <.001). In a multivariate analysis, BMI in the lower and upper quartiles was associated with disease exacerbation (HR 3.212 and 4.651, respectively, p =.016) and anti-tumor necrosis factor (TNF) therapy (HR 4.489 and 3.972, respectively, p =.021). Conclusions: BMI in the lower and upper quartiles was associated with more severe disease course in children with IBD. BMI may serve as a simple and highly accessible predictor of pediatric IBD course and prognosis.
AB - Objectives: Inflammatory bowel disease (IBD) has been historically associated with underweight and malnutrition. The impact of both underweight and obesity on the clinical course of IBD in adults is controversial. This study described the association between body mass index (BMI) at diagnosis to disease course in children with IBD. Methods: We reviewed the medical records of children with IBD from the database of the ‘Dana-Dwek’ Children’s Hospital between 2010 and 2016. Demographic and anthropometric data were collected as were disease characteristics, course and therapy. Patients were categorized in quartiles according to BMI percentiles at diagnosis (Q1–Q4). Results: Of 100 children who were identified, 62 had Crohn’s disease (CD) and 38 had ulcerative colitis (UC). The median age (interquartile range, IQR) at diagnosis was 13.7 (range 11.9–15.2) years. The median (IQR) follow-up was 2.1 (1.2–3.8) years. At diagnosis, 46 children (46%) were in Q1, 20 (20%) in Q2, 19 (19%) in Q3 and 15 (15%) in Q4. Prolonged time to diagnosis was associated with BMI in Q1 and Q4, as well as high disease activity at diagnosis (p <.001). In a multivariate analysis, BMI in the lower and upper quartiles was associated with disease exacerbation (HR 3.212 and 4.651, respectively, p =.016) and anti-tumor necrosis factor (TNF) therapy (HR 4.489 and 3.972, respectively, p =.021). Conclusions: BMI in the lower and upper quartiles was associated with more severe disease course in children with IBD. BMI may serve as a simple and highly accessible predictor of pediatric IBD course and prognosis.
KW - BMI
KW - IBD
KW - children
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85046008675&partnerID=8YFLogxK
U2 - 10.1080/00365521.2018.1464595
DO - 10.1080/00365521.2018.1464595
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C2 - 29688090
AN - SCOPUS:85046008675
VL - 53
SP - 708
EP - 713
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 6
ER -