Hexosaminidase A in amniotic fluid of Tay-Sachs fetuses

B. Geiger, R. Navon, R. Arnon

Research output: Contribution to journalArticlepeer-review


Hexosaminidase A is present in relatively low concentrations in cell-free amniotic fluids from pregnancies with Tay-Sachs fetuses. This isoenzyme was determined by an immunological procedure, radial immunodiffusion, by which hexosaminidase A can be directly and specifically detected, even in the presence of excess amounts of hexosaminidase B. No hexosaminidase A could be detected by the same procedure in Tay-Sachs fetal tissues, implying that this isoenzyme in the amniotic fluid originates from the mother.

Original languageEnglish
Pages (from-to)1131-1133
Number of pages3
JournalClinical Chemistry
Issue number7
StatePublished - 1978
Externally publishedYes


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