TY - JOUR
T1 - Hexasomy of chromosome 8 and trisomy of chromosome 11 characterize two karyotypically independent clones in a case of acute non-lymphocytic leukemia. Conventional cytogenetic and FISH investigation
AU - Trakhtenbrot, Luba
AU - Rosner, Esther
AU - Gipsh, Nelly
AU - Berman, Sarah
AU - Sofer, Orit
AU - Brok-Simoni, Frida
AU - Rechavi, Gideon
AU - Ben-Bassat, Isaac
N1 - Funding Information:
This work was supported in part by the Israel Cancer Research Fund.
PY - 1995/11
Y1 - 1995/11
N2 - A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics and FISH. Significant quantitative differences between data obtained by metaphase and interphase analysis of the hexasomy 8 clone were observed. A difference in the sensitivity to chemotherapy of the two clones was found: while the hexasomy 8 clone markedly decreased in response to treatment, the trisomy 11 clone remained unchanged.
AB - A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics and FISH. Significant quantitative differences between data obtained by metaphase and interphase analysis of the hexasomy 8 clone were observed. A difference in the sensitivity to chemotherapy of the two clones was found: while the hexasomy 8 clone markedly decreased in response to treatment, the trisomy 11 clone remained unchanged.
UR - http://www.scopus.com/inward/record.url?scp=0029589938&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(95)00107-7
DO - 10.1016/0165-4608(95)00107-7
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AN - SCOPUS:0029589938
SN - 0165-4608
VL - 85
SP - 1
EP - 4
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
