TY - JOUR
T1 - Herpetic Anterior Uveitis–Analysis of Presumed and PCR Proven Cases
AU - Neumann, Ron
AU - Barequet, Dana
AU - Rosenblatt, Amir
AU - Amer, Radgonde
AU - Ben-Arie-Weintrob, Yael
AU - Hareuveni-Blum, Tamar
AU - Vishnevskia-Dai, Vicktoria
AU - Raskin, Eyal
AU - Blumenfeld, Oren
AU - Shulman, Shiri
AU - Sanchez, Juan M.
AU - Flores, Victor
AU - Habot-Wilner, Zohar
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019/2/17
Y1 - 2019/2/17
N2 - Purpose: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. Methods: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR). Results: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis. HSV eyes, compared to VZV, had a higher recurrence rate, corneal involvement, KPs, iris atrophy, elevated IOP and posterior synechia (p < 0.05). VZV patients had more frequent immunomodulatory treatments and history of systemic herpetic disease (p < 0.05). Fifty-nine (52.7%) eyes had recurrent disease. Iris atrophy was associated with a higher prevalence of posterior synechia, dilated distorted pupil, and high IOP (p < 0.05). Conclusion: Different HAU-causing Herpesviridae produce common clinical findings; therefore, PCR should be used more often to confirm specific diagnosis. Iris atrophy was associated with more severe disease.
AB - Purpose: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. Methods: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR). Results: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis. HSV eyes, compared to VZV, had a higher recurrence rate, corneal involvement, KPs, iris atrophy, elevated IOP and posterior synechia (p < 0.05). VZV patients had more frequent immunomodulatory treatments and history of systemic herpetic disease (p < 0.05). Fifty-nine (52.7%) eyes had recurrent disease. Iris atrophy was associated with a higher prevalence of posterior synechia, dilated distorted pupil, and high IOP (p < 0.05). Conclusion: Different HAU-causing Herpesviridae produce common clinical findings; therefore, PCR should be used more often to confirm specific diagnosis. Iris atrophy was associated with more severe disease.
KW - Anterior uveitis
KW - CMV
KW - HSV
KW - PCR
KW - VZV
KW - cytomegalovirus
KW - herpes simplex virus
KW - herpetic anterior uveitis
KW - polymerase chain reaction
KW - varicella zoster virus
UR - http://www.scopus.com/inward/record.url?scp=85054914428&partnerID=8YFLogxK
U2 - 10.1080/09273948.2018.1483521
DO - 10.1080/09273948.2018.1483521
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 30311824
AN - SCOPUS:85054914428
SN - 0927-3948
VL - 27
SP - 211
EP - 218
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 2
ER -