TY - CHAP
T1 - Herpes virus infection of the peripheral nervous system
AU - Steiner, Israel
PY - 2013
Y1 - 2013
N2 - Among the human herpes viruses, three are neurotropic and capable of producing severe neurological abnormalities: herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Both the acute, primary infection and the reactivation from the site of latent infection, the dorsal sensory ganglia, are associated with severe human morbidity and mortality. The peripheral nervous system is one of the major loci affected by these viruses. The present review details the virology and molecular biology underlying the human infection. This is followed by detailed description of the symtomatology, clinical presentation, diagnosis, course, therapy, and prognosis of disorders of the peripheral nervous system caused by these viruses.
AB - Among the human herpes viruses, three are neurotropic and capable of producing severe neurological abnormalities: herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Both the acute, primary infection and the reactivation from the site of latent infection, the dorsal sensory ganglia, are associated with severe human morbidity and mortality. The peripheral nervous system is one of the major loci affected by these viruses. The present review details the virology and molecular biology underlying the human infection. This is followed by detailed description of the symtomatology, clinical presentation, diagnosis, course, therapy, and prognosis of disorders of the peripheral nervous system caused by these viruses.
KW - Herpes simplex virus
KW - Herpes viruses
KW - Latent infection
KW - Peripheral neuropathy
KW - Varicella-zoster virus
UR - http://www.scopus.com/inward/record.url?scp=84881499569&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-52902-2.00031-X
DO - 10.1016/B978-0-444-52902-2.00031-X
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C2 - 23931801
AN - SCOPUS:84881499569
T3 - Handbook of Clinical Neurology
SP - 543
EP - 558
BT - Handbook of Clinical Neurology
PB - Elsevier B.V.
ER -