Herpes simplex virus infection in a hyper-ige patient: Appearance of unusual mass lesions

Klilah Hershko, Alon Y. Hershko, Vera Leibovici, Karen Meir, Arieh Ingber

Research output: Contribution to journalArticlepeer-review

Abstract

A 7-year-old girl presented with large soft masses rising from the nostril and from behind the ear. She had previously been diagnosed as suffering from hyper-IgE syndrome. The presence of herpes simplex virus infection within these lesions was confirmed by biopsy and immunohistochemical studies. The mass lesions did not respond to antibacterial therapy with cefazolin, but improved promptly under antiviral therapy with acyclovir. Immunological studies revealed a mild decrease in the CD4 cell population. Based on our results and on the relevant literature we propose an immunological mechanism for this unique manifestation of herpes simplex virus infection in hyper-IgE syndrome.

Original languageEnglish
Pages (from-to)204-205
Number of pages2
JournalActa Dermato-Venereologica
Volume82
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • CD4 deficiency
  • Cutaneous nodules
  • Hypereosinophilia
  • Job's syndrome

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