Herpes simplex-associated erythema multiforme (HAEM): A clinical therapeutic dilemma

Joseph Katz*, Avi Livneh, Joshua Shemer, Yehuda L. Danon, Benjamin Peretz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Erythema multiforme of the mouth is an acute vesiculoulcerative lesion, which presents a diagnostic and therapeutic challenge to the clinician. Herpes simplex is described as the most frequent cause of this disease. Controversy exists in the literature as to the definition of oral erythema multiforme and the role of systemic corticosteroids in its treatment. Recent treatment protocols advocate the use of systemic Acyclovir, especially in cases triggered by the herpes simplex virus. Two cases of successful treatment of oral erythema multiforme with systemic corticosteroids after Acyclovir treatment had failed are presented.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalPediatric Dentistry
Issue number6
StatePublished - Sep 1999


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