Hereditary ovarian cancer

A. Neri*, D. Rabinerson, B. Kaplan, H. Levavi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Hereditary ovarian cancer occurs rarely in the general population but may appear in up to 85% of the offspring of affected women. Pedigree analysis remains the main diagnostic tool. Aberrations of BRCA-1 gene, located on 17q12-21, are considered to be the reason for the genetic expression of ovarian cancer. Hereditary ovarian cancer is characterized by bilateralism, usually stage III, at operative diagnosis, mostly serous cystadenocarcinoma type and relatively early age at onset. Hence, early follow-up is recommended in high risk patients. Prophylactic removal of the uterus and the adnexae is indicated in patients at risk.

Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume31
Issue number2-3
StatePublished - 1995
Externally publishedYes

Keywords

  • Inheritance
  • Ovarian cancer

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