Hereditary hearing loss: From human mutation to mechanism

Danielle R. Lenz, Karen B. Avraham

Research output: Contribution to journalArticlepeer-review

Abstract

The genetic heterogeneity of hereditary hearing loss is thus far represented by hundreds of genes encoding a large variety of proteins. Mutations in these genes have been discovered for patients with different modes of inheritance and types of hearing loss, ranging from syndromic to non-syndromic and mild to profound. In many cases, the mechanisms whereby the mutations lead to hearing loss have been partly elucidated using cell culture systems and mouse and other animal models. The discovery of the genes has completely changed the practice of genetic counseling in this area, providing potential diagnosis in many cases that can be coupled with clinical phenotypes and offer predictive information for families. In this review we provide three examples of gene discovery in families with hereditary hearing loss, all associated with elucidation of some of the mechanisms leading to hair cell degeneration and pathology of deafness.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalHearing Research
Volume281
Issue number1-2
DOIs
StatePublished - Nov 2011

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