TY - JOUR
T1 - Herbimycin A in the treatment of experimental proliferative vitreoretinopathy
T2 - Toxicity and efficacy study
AU - Imai, Kazuyuki
AU - Loewenstein, Anat
AU - Koroma, Barba
AU - Grebe, Rhonda
AU - De Juan, Eugene
PY - 2000/5
Y1 - 2000/5
N2 - Background: Proliferative vitreoretinopathy (PVR) is partially caused by peptide growth factors, stimulating the cell by binding to a transmembrane tyrosine kinase receptor. We studied the effects of herbimycin A (HA), a tyrosine kinase inhibitor, in PVR. Methods: Toxicity studies: Electroretinography and histological studies were performed after intravitreal injection of HA. Efficacy studies: Homologous rabbit dermal fibroblasts were injected intravitreally, followed by injection of HA. The presence of tractional retinal detachment (TRD) and severity of inflammation were assessed. Results: Toxicity studies: Eyes injected with HA exhibited decrease in B-wave amplitude initially, with subsequent recovery. Histologically, damage to photoreceptors was evident after injection of high but not of low doses of HA. Efficacy studies: Inflammatory response and the development of TRD were significantly reduced with all doses of HA.. Conclusions: HA (20 μM) was found to be effective and safe in preventing the development of inflammation and TRD.
AB - Background: Proliferative vitreoretinopathy (PVR) is partially caused by peptide growth factors, stimulating the cell by binding to a transmembrane tyrosine kinase receptor. We studied the effects of herbimycin A (HA), a tyrosine kinase inhibitor, in PVR. Methods: Toxicity studies: Electroretinography and histological studies were performed after intravitreal injection of HA. Efficacy studies: Homologous rabbit dermal fibroblasts were injected intravitreally, followed by injection of HA. The presence of tractional retinal detachment (TRD) and severity of inflammation were assessed. Results: Toxicity studies: Eyes injected with HA exhibited decrease in B-wave amplitude initially, with subsequent recovery. Histologically, damage to photoreceptors was evident after injection of high but not of low doses of HA. Efficacy studies: Inflammatory response and the development of TRD were significantly reduced with all doses of HA.. Conclusions: HA (20 μM) was found to be effective and safe in preventing the development of inflammation and TRD.
UR - http://www.scopus.com/inward/record.url?scp=0034036278&partnerID=8YFLogxK
U2 - 10.1007/s004170050376
DO - 10.1007/s004170050376
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C2 - 10901476
AN - SCOPUS:0034036278
SN - 0721-832X
VL - 238
SP - 440
EP - 447
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
IS - 5
ER -
