Hepatotoxicity, leucopenia and neutropenia associated with olanzapine therapy

Eleonora Tchernichovsky, Pinkhas Sirota*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Hepatotoxicity, leukopenia and neutropenia are rarely associated with atypical antipsychotic drug therapy. The authors describe a case of a schizophrenic patient, who was treated twice with olanzapine, and who developed an increase of hepatic enzymes, jaundice, reduced WBC, neutropenia, and a high temperature. The patient was diagnosed as suffering from hepatocellular hepatitis, neutropenia and leucopenia. Neuroleptic treatment was discontinued immediately and the patient exhibited consequential clinical improvement. A review of the literature is included.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalInternational Journal of Psychiatry in Clinical Practice
Issue number3
StatePublished - Sep 2004
Externally publishedYes


  • Drug-induced hepatitis
  • Leucopenia
  • Neutropenia
  • Olanzapine


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