TY - JOUR
T1 - Hepatotoxicity, leucopenia and neutropenia associated with olanzapine therapy
AU - Tchernichovsky, Eleonora
AU - Sirota, Pinkhas
PY - 2004/9
Y1 - 2004/9
N2 - Hepatotoxicity, leukopenia and neutropenia are rarely associated with atypical antipsychotic drug therapy. The authors describe a case of a schizophrenic patient, who was treated twice with olanzapine, and who developed an increase of hepatic enzymes, jaundice, reduced WBC, neutropenia, and a high temperature. The patient was diagnosed as suffering from hepatocellular hepatitis, neutropenia and leucopenia. Neuroleptic treatment was discontinued immediately and the patient exhibited consequential clinical improvement. A review of the literature is included.
AB - Hepatotoxicity, leukopenia and neutropenia are rarely associated with atypical antipsychotic drug therapy. The authors describe a case of a schizophrenic patient, who was treated twice with olanzapine, and who developed an increase of hepatic enzymes, jaundice, reduced WBC, neutropenia, and a high temperature. The patient was diagnosed as suffering from hepatocellular hepatitis, neutropenia and leucopenia. Neuroleptic treatment was discontinued immediately and the patient exhibited consequential clinical improvement. A review of the literature is included.
KW - Drug-induced hepatitis
KW - Leucopenia
KW - Neutropenia
KW - Olanzapine
UR - http://www.scopus.com/inward/record.url?scp=6044256151&partnerID=8YFLogxK
U2 - 10.1080/13651500410005577
DO - 10.1080/13651500410005577
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AN - SCOPUS:6044256151
SN - 1365-1501
VL - 8
SP - 173
EP - 177
JO - International Journal of Psychiatry in Clinical Practice
JF - International Journal of Psychiatry in Clinical Practice
IS - 3
ER -
