Hepatotoxic effects of repeated administration of oriental hornet (vespa orientalis) venom

M. G. Neuman*, M. Waron, E. Scapa, J. Eshchar, J. S. Ishay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Venom sac extract (VSE) of the Oriental hornet (Vespa orientalis) has been shown to exert a toxic effect on hepatic cells. The present work set out to examine its effect on liver cells using serum levels of a lysosomal hydrolase as a marker of injury in rats. Serum activities of beta‐N‐acetyl hexosaminidase (BNAH; EC were found to be positively correlated with the number of treatments received by the rats. The maximal elevation occurred from the third to the sixth day and comprised a 2‐3‐fold increase over the control mean level. This enhancement effect was reversible. The rat envenomend for 2 wk showed 3.5 times as much BNAH activity as in control rats. Biochemical analysis revealed increased specific activity of the lysosomal enzyme in rats treated repeatedly with VSE.

Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalJournal of Clinical Laboratory Analysis
Issue number6
StatePublished - 1990
Externally publishedYes


  • Oriental hornet
  • hepatotoxicity
  • hexosaminidase
  • venom


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